Current understanding and problems of steroid-resistant asthma
نویسندگان
چکیده
منابع مشابه
Steroid-resistant asthma.
The current study examined whether alterations in glucocorticoid receptor (GR) binding contribute to poor response to glucocorticoid therapy in asthma. 29 asthma patients with forced expiratory volume in 1 s (FEV1) < 70% predicted were studied. Patients were classified as steroid sensitive (SS) if their morning FEVI increased > 30% after a I-wk course of oral prednisone 20 mg twice daily and st...
متن کاملSteroid resistant asthma.
Inspite of very safe and effective treatment, Bronchial asthmatics do not respond well in 5-10% of cases which are labelled as Refractory Asthma. Besides compliance, presence of psychogenic and trigger factors and comorbid illness, steroid insensitiveness or resistance may play a significant role in the poorly controlled/responding asthmatics. Type I Steroid resistance is due to lack of binding...
متن کاملShort paper Pseudo-steroid resistant asthma
Background—Steroid resistant asthma (SRA) represents a small subgroup of those patients who have asthma and who are diYcult to manage. Two patients with apparent SRA are described, and 12 additional cases who were admitted to the same hospital are reviewed. Methods—The subjects were selected from a tertiary hospital setting by review of all asthma patients admitted over a two year period. Subje...
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Factor XIII or "fibrin-stabilizing factor," is a transglutaminase circulates in the blood circulation as a hetero tetramer with two catalytic A subunits and two carrier B subunits. This important coagulation factor has a crucial role in clotting cascade and produces strong covalent bonds between soluble formed fibrin monomers during coagulation. This stable cross linked fibrin strands are resis...
متن کاملSteroid-resistant nephrotic syndrome: past and current perspectives
Patients with steroid-resistant nephrotic syndrome (SRNS) represent a challenging subset of patients with nephrotic syndrome who often fail standard immunosuppression and have a higher likelihood of progressing to end-stage renal disease. Appropriate treatment of SRNS requires an adequate understanding of the historical treatment, renal histopathology, and genetics associated with the disease. ...
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ژورنال
عنوان ژورنال: Allergology International
سال: 2000
ISSN: 1323-8930
DOI: 10.1046/j.1440-1592.2000.00191.x